(E)-Cinnamaldehyde is an E (trans) stereoisomer found in Cinnamaldehyde. This s one of the parents of the cinnamaldehyde class. It serves as an agent for hypoglycemic control and is an EC 4.3.1.24 (phenylalanine ammonia-lyase) inhibitor and a vasodilator. And it is an antifungal agent, a flavoring agent, and a plant metabolite as well as a sensitizer. It is a 3-phenylprop-2-enal and one of the cinnamaldehydes.
The Drug Indication
Cinnamaldehyde is authorized by the FDA to be used in allergy-related epicutaneous patch tests that are suggested to aid in diagnosing allergic contact skin dermatitis (ACD) for people who are six years old or older. Research chemical online and you can find thousands.
Therapeutic Uses
Cinnamonum Zylanicum (cinnamon) is used extensively in the traditional medical treatment system as a treatment for diabetes in India. The current study was designed to determine and isolate likely antidiabetic substances. Cinnamaldehyde was given at various dosages (5, 10, 20, and 10 mg/kg body weight) during 45-days before streptozotocin (STZ) (60 mg/kg BW)-induced male diabetic Wistar rats. The blood glucose concentrations were significantly (p<0.05) reduced in the dose-dependent way (63.29 percent) when compared with the baseline. In addition, oral administration of Cinnamaldehyde (20 mg/kg BW) significantly decreased glycosylated hemoglobin (HbA(1C)), total serum cholesterol, triglyceride levels, and at the same time markedly increased plasma insulin, hepatic glycogen, and high-density lipoprotein-cholesterol levels.
Fatal Dose
The likely lethal oral dose for human beings can range from 0.5 to 5 grams/kg for 70kg of a person. Both the pure aldehyde and the oil are irritating, particularly when they are not dilute. They also can cause irritation and degeneration of the digestive mucosa. In addition, contacting the skin for a prolonged period (more than 48 hours) may result in minor partial thickness skin burns.
The Route to Elimination
Cinnamaldehyde is processed and excreted chiefly in the urine and to a lesser degree within the feces. When administered intraperitoneally or orally to mice and rats, 969-98% in the amount of Cinnamaldehyde found in urine and feces in less than 24 hours.
Metabolism/Metabolites
The metabolism of trans-[3-14C] cinnamaldehyde was investigated in male and female Fischer 344 rats and CD1 mice at doses of 2 and 250 mg/kg BW given by IP injection and in males at 250 mg/kg by oral gavage. Urinary metabolites could be identified by their chromatographic features. In both species, the major urinary metabolite was hippuric acid accompanied by 3-hydroxy-3-phenyl propionic acid, benzoic acid, and benzoyl glucuronide. The Glycine conjugate of cinnamic acids was produced to a large extent only in mice. The metabolic process of oxidation of Cinnamaldehyde mirrors the metabolism of the cinnamic acids via beta-oxidation that is similar to the fatty acid metabolism.
Uses
For Cinnamaldehyde (USEPA/OPP Pesticide Code 040506) Active products with labels that match. SRP is registered to be used in the U.S., but approved pesticide applications may change frequently. And thus the federal, state, and local authorities should be consulted regarding currently approved uses. When electroplating, Cinnamaldehyde can be used to brighten the process. Other applications include its use as a repellent for animals and its inclusion in compositions that draw insects, and the demonstration of positive antifungal action.
